Packaging and storage
Preserve in single-dose or in multiple-dose containers, preferably of Type I glass. Injection may be packaged in 50-mL multiple-dose containers.
Injections that are of such concentration that they are not intended for direct injection into tissues are labeled to indicate that they are to be diluted prior to administration.
Place in a separator a volume of Injection equivalent to about 300 mg of lidocaine hydrochloride, and extract with four 15-mL portions of chloroform, discarding the chloroform extracts. Add 2 mL of 2 N sodium hydroxide to the aqueous solution remaining in the separator, and extract with four 15-mL portions of chloroform. Combine the chloroform extracts, and evaporate with the aid of a current of warm air to dryness. Dissolve the crystals so obtained in solvent hexane, evaporate with the aid of warm air, and dry the residue in vacuum over silica gel for 24 hours: the residue so obtained responds to Identification
It meets the requirements under Injections 1