Assay—
Standard preparation—
Dissolve an accurately weighed quantity of
USP Maltol RS in 0.1 N hydrochloric acid, and dilute quantitatively, and stepwise if necessary, with 0.1 N hydrochloric acid to obtain a solution having a known concentration of about 0.01 mg per mL.
Assay preparation—
Transfer about 50 mg of Maltol, accurately weighed, to a 250-mL volumetric flask, dissolve in and dilute with 0.1 N hydrochloric acid to volume, and mix. Pipet 5 mL of this solution into a 100-mL volumetric flask, dilute with 0.1 N hydrochloric acid to volume, and mix.
Procedure—
With a suitable spectrophotometer, using 0.1 N hydrochloric acid as a blank, concomitantly determine the absorbances of the
Standard preparation and the
Assay preparation at the wavelength of maximum absorbance at about 274 nm. Calculate the quantity, in mg, of C
6H
6O
3 in the portion of Maltol taken by the formula:
5000C(AU / AS),
in which
C is the concentration, in mg per mL, of
USP Maltol RS in the
Standard preparation; and
AU and
AS are the absorbances obtained from the
Assay preparation and the
Standard preparation, respectively.
;)
197K
.
and 164