Benzenemethanaminium,
N,
N-dimethyl-
N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]-, chloride.
Benzyldimethyl[2-[2-[
p-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]ammonium chloride
[
121-54-0].
Packaging and storage—
Preserve in tight, light-resistant containers.
Identification—
A:
To 1 mL of a solution (1 in 100) add 2 mL of alcohol, 0.5 mL of 2 N nitric acid, and 1 mL of
silver nitrate TS: a white precipitate, which is insoluble in 2 N nitric acid but soluble in 6 N ammonium hydroxide, is formed.
B:
A solution (1 in 100) forms precipitates with 2 N nitric acid and with
mercuric chloride TS, both of which dissolve upon the addition of alcohol.
C:
Dissolve 0.1 g in 1 mL of sulfuric acid, add 0.1 g of potassium nitrate, and heat on a steam bath for 3 minutes. Cautiously dilute the solution with water to 10 mL, add 0.5 g of granulated zinc, and warm the mixture for 10 minutes. Cool, add 0.2 g of sodium nitrite to 1 mL of the clear liquid, and add this mixture to 20 mg of naphthol dipotassium disulfonate or naphthol disodium disulfonate in 1 mL of ammonium hydroxide: the solution turns orange-red, and a brown precipitate may be formed.
Limit of ammonium compounds—
To 5 mL of a solution (1 in 50) add 3 mL of 1 N sodium hydroxide, and heat to boiling: the odor of ammonia is not perceptible.
Assay—
Dissolve about 0.3 g of Benzethonium Chloride, accurately weighed, in 75 mL of water contained in a glass-stoppered, 250-mL flask. Add 0.4 mL of bromophenol blue solution (1 in 2000), 10 mL of chloroform, and 1 mL of 1 N sodium hydroxide. Titrate with 0.02 M sodium tetraphenylboron VS until the blue color disappears from the chloroform layer. Add the last portions of the sodium tetraphenylboron solution dropwise, agitating vigorously after each addition. Each mL of 0.02 M sodium tetraphenylboron is equivalent to 8.962 mg of C27H42ClNO2.
Auxiliary Information—
Staff Liaison :
Behnam Davani, Ph.D., MBA, Senior Scientist
Expert Committee : (MDAA05) Monograph Development-Antivirals and Antimicrobials
USP29–NF24 Page 247
Pharmacopeial Forum : Volume No. 27(1) Page 1754
Phone Number : 1-301-816-8394
;)
731
—
Dry it at 105
for 4 hours: it loses not more than 5.0% of its weight.