Packaging and storage— Preserve in tight containers, at controlled room temperature, remote from fire.

Residual solvents 467: meets the requirements.

Assay— Transfer to a 400-mL beaker 5 mL of Salicylic Acid Collodion, accurately measured, rinse the measuring device with three 10-mL portions of a mixture of ether and alcohol (3:1) that previously has been neutralized to bromothymol blue TS, and add the rinsings to the beaker. Add, with stirring, 5 mL of sodium lauryl sulfate solution (1 in 10) that previously has been neutralized with 0.1 N hydrochloric acid to the distinct yellow color of bromothymol blue TS, and finally add 20 mL of water. Mix, add 5 drops of bromothymol blue TS, and titrate the mixture with 0.1 N sodium hydroxide VS. Each mL of 0.1 N sodium hydroxide is equivalent to 13.81 mg of C7H6O3.

Expert Committee : (MDOOD05) Monograph Development-Ophthalmics Oncologics and Dermatologicals

USP29–NF24 Page 1941

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