FOR SOLID PACKAGED IN SINGLE-UNIT CONTAINERS : meets the requirements.

(Official January 1, 2007)

Standard preparation— Prepare as directed for Standard preparation under Iodometric Assay—Antibiotics 425, using USP Penicillin G Potassium RS.

Assay preparation— Dilute an accurately measured volume of solution of Penicillin G Potassium for Oral Solution, constituted as directed in the labeling, quantitatively and stepwise with Buffer No. 1 (see Media and Diluents under Antibiotics—Microbial Assay 81) to obtain a solution containing about 2000 Penicillin G Units per mL. Pipet 2 mL of this solution into each of two glass-stoppered, 125-mL conical flasks.

Procedure— Proceed as directed for Procedure under Iodometric Assay—Antibiotics 425. Calculate the quantity, in Penicillin G Units, in each mL of the constituted solution of Penicillin G Potassium for Oral Solution taken by the formula: in which L is the labeled quantity, in Penicillin G Units per mL in the constituted solution of Penicillin G Potassium for Oral Solution, and D is the concentration, in Units per mL, of Penicillin G in the Assay preparation on the basis of the labeled quantity in the constituted solution of Penicillin G Potassium for Oral Solution and the extent of dilution.