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197K
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Obtain the test specimen as follows. Transfer a quantity of Intramammary Infusion, equivalent to about 500 mg of cloxacillin, to a 50-mL centrifuge tube, add 15 mL of isooctane, mix, and centrifuge. Decant and discard the isooctane. Wash the residue with two 15-mL portions of isooctane and two 15-mL portions of ethyl ether, and discard the washings. Dry the residue in a current of air.
71 (where labeled as being sterile)—
It meets the requirements when tested as directed for Direct Inoculation of the Culture Medium under Test for Sterility of the Product to be Examined, except to use Fluid Thioglycollate Medium containing polysorbate 80 solution (1 in 200) and an amount of sterile penicillinase sufficient to inactivate the cloxacillin in each tube, to use Soybean–Casein Digest Medium containing polysorbate 80 solution (1 in 200) and an amount of sterile penicillinase sufficient to inactivate the cloxacillin in each tube, and to shake the tubes once daily.
921:
not more than 1.0%, 20 mL of a mixture of toluene and methanol (7:3) being used in place of methanol in the titration vessel.
467:
meets the requirements.
81, expelling the contents of 1 syringe of Intramammary Infusion into a high-speed glass blender jar containing 499.0 mL of Buffer No. 1 and 1.0 mL of polysorbate 80, and blending for 3 to 5 minutes. Allow to stand for 10 minutes, and dilute an accurately measured volume of the aqueous phase quantitatively and stepwise with Buffer No. 1 to obtain a Test Dilution having a concentration assumed to be equal to the median dose level of the Standard.