U.S. PHARMACOPEIA

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Tacrine Hydrochloride: White powder. Freely soluble in water, in 0.1 N hyddrochloric acid, in pH 4.0 acetate buffer, in phosphate buffer (pH between 7.0 and 7.4), in methanol, in dimethylsulfoxide, in alcohol, and in propylene glycol; sparingly soluble in linoleic acid and in polyethylene glycol 400.
Talc: Very fine, white or grayish-white, crystalline powder. Is unctuous, adheres readily to the skin, and is free from grittiness. NF category: Glidant and/or anticaking agent; tablet and/or capsule lubricant.
Tamoxifen Citrate: White, fine, crystalline powder. Very slightly soluble in water, in acetone, in chloroform, and in alcohol; soluble in methanol. Melts at about 142, with decomposition.
Tannic Acid: Amorphous powder, glistening scales, or spongy masses, varying in color from yellowish-white to light brown. Is odorless or has a faint, characteristic odor, and has a strongly astringent taste. Very soluble in water, in acetone, and in alcohol; is freely soluble in diluted alcohol, and only slightly soluble in dehydrated alcohol; practically insoluble in benzene, in chloroform, in ether, and in solvent hexane; 1 g dissolves in about 1 mL of warm glycerin.
Tartaric Acid: Colorless or translucent crystals or white, fine to granular, crystalline powder. Is odorless, has an acid taste, and is stable in air. Very soluble in water; freely soluble in alcohol. NF category: Acidifying agent.
Taurine: White crystals or crystalline powder. Soluble in water.
Technetium Tc 99m Aggregated Albumin Injection: Milky suspension, from which particles settle upon standing.
Technetium Tc 99m Pentetate Injection: Clear, colorless solution.
Sodium Pertechnetate Tc 99m Injection: Clear, colorless solution.
Technetium Tc 99m (Pyro- and trimeta-) Phosphates Injection: Clear solution.
Technetium Tc 99m Sulfur Colloid Injection: Colloidal dispersion. Slightly opalescent, colorless to light tan liquid.
Temazepam: White or nearly white, crystalline powder. Very slightly soluble in water; sparingly soluble in alcohol. Melts between 157 and 163, within a 3 range.
Terazosin Hydrochloride: White to pale yellow, crystalline powder. Freely soluble in isotonic saline solution; soluble in methanol and in water; slightly soluble in alcohol and in 0.1 N hydrochloric acid; very slightly soluble in chloroform; practically insoluble in acetone and in hexanes.
Terbutaline Sulfate: White to gray-white, crystalline powder. Is odorless or has a faint odor of acetic acid. Soluble in water and in 0.1 N hydrochloric acid; slightly soluble in methanol; insoluble in chloroform.
Terpin Hydrate: Colorless, lustrous crystals or white powder. Has a slight odor, and effloresces in dry air. A hot solution (1 in 100) is neutral to litmus. When dried in vacuum at 60 for 2 hours, it melts at about 103. Slightly soluble in water, in chloroform, and in ether; very soluble in boiling alcohol; soluble in alcohol; sparingly soluble in boiling water.
Testolactone: White to off-white, practically odorless, crystalline powder. Melts at about 218. Slightly soluble in water and in benzyl alcohol; soluble in alcohol and in chloroform; insoluble in ether and in solvent hexane.
Testosterone: White or slightly creamy white crystals or crystalline powder. Is odorless, and is stable in air. Practically insoluble in water; freely soluble in dehydrated alcohol and in chloroform; soluble in dioxane and in vegetable oils; slightly soluble in ether.
Testosterone Cypionate: White or creamy white, crystalline powder. Is odorless or has a slight odor, and is stable in air. Insoluble in water; freely soluble in alcohol, in chloroform, in dioxane, and in ether; soluble in vegetable oils.
Testosterone Enanthate: White or creamy white, crystalline powder. Is odorless or has a faint odor characteristic of heptanoic acid. Insoluble in water; very soluble in ether; soluble in vegetable oils.
Testosterone Propionate: White or creamy white crystals or crystalline powder. Is odorless and is stable in air. Insoluble in water; freely soluble in alcohol, in dioxane, in ether, and in other organic solvents; soluble in vegetable oils.
Tetanus Immune Globulin: Transparent or slightly opalescent liquid, practically colorless and practically odorless. May develop a slight granular deposit during storage.
Tetanus Toxoid: Clear, colorless to brownish-yellow, or slightly turbid liquid, free from evident clumps or particles, having a characteristic odor or an odor of formaldehyde.
Tetanus Toxoid Adsorbed: Turbid, white, slightly gray, or slightly pink suspension, free from evident clumps after shaking.
Tetanus and Diphtheria Toxoids Adsorbed for Adult Use: Turbid, white, slightly gray, or cream-colored suspension, free from evident clumps after shaking.
Tetracaine: White or light yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, in ether, in benzene, and in chloroform.
Tetracaine Hydrochloride: Fine, white, crystalline, odorless powder. Has a slightly bitter taste followed by a sense of numbness. Its solutions are neutral to litmus. Melts at about 148, or may occur in either of two other polymorphic modifications that melt at about 134 and 139, respectively. Mixtures of the forms may melt within the range of 134 to 147. Is hygroscopic. Very soluble in water; soluble in alcohol; insoluble in ether and in benzene.
Tetracycline: Yellow, odorless, crystalline powder. Is stable in air, but exposure to strong sunlight causes it to darken. It loses potency in solutions of pH below 2, and is rapidly destroyed by alkali hydroxide solutions. Very slightly soluble in water; freely soluble in dilute acid and in alkali hydroxide solutions; sparingly soluble in alcohol; practically insoluble in chloroform and in ether.
Tetracycline Hydrochloride: Yellow, odorless, crystalline powder. Is moderately hygroscopic. Is stable in air, but exposure to strong sunlight in moist air causes it to darken. It loses potency in solution at a pH below 2, and is rapidly destroyed by alkali hydroxide solutions. Soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Tetrahydrozoline Hydrochloride: White, odorless solid. Melts at about 256, with decomposition. Freely soluble in water and in alcohol; very slightly soluble in chloroform; practically insoluble in ether.
Thalidomide: White to off-white powder. Very soluble in dimethylformamide, in dioxane, and in pyridine; sparingly soluble in acetone, in butyl acetate, in ethanol, in ethyl acetate, in glacial acetic acid, in methanol, and in water; practically insoluble in benzene, in chloroform, and in ether.
Theophylline: White, odorless, crystalline powder, having a bitter taste. Is stable in air. Slightly soluble in water, but more soluble in hot water; freely soluble in solutions of alkali hydroxides and in ammonia; sparingly soluble in alcohol, in chloroform, and in ether.
Theophylline Sodium Glycinate: White, crystalline powder having a slight ammoniacal odor and a bitter taste. Freely soluble in water; very slightly soluble in alcohol; practically insoluble in chloroform.
Thiabendazole: White to practically white, odorless or practically odorless powder. Practically insoluble in water; slightly soluble in acetone and in alcohol; very slightly soluble in chloroform and in ether.
Thiacetarsamide: White to yellowish, crystalline powder. Sparingly soluble in cold dehydrated alcohol, in cold methanol, and in cold water; more soluble in water above 90; soluble in warm dehydrated alcohol and in warm methanol; insoluble in warm isopropyl alcohol. pKa is 4.
Thiamine Hydrochloride: White crystals or crystalline powder, usually having a slight, characteristic odor. When exposed to air, the anhydrous product rapidly absorbs about 4% of water. Melts at about 248, with some decomposition. Freely soluble in water; soluble in glycerin; slightly soluble in alcohol; insoluble in ether and in benzene.
Thiamine Mononitrate: White crystals or crystalline powder, usually having a slight, characteristic odor. Sparingly soluble in water; slightly soluble in alcohol; very slightly soluble in chloroform.
Thiethylperazine Maleate: Yellowish, granular powder. Is odorless or has not more than a slight odor. Melts at about 183, with decomposition. Practically insoluble in water; slightly soluble in methanol; practically insoluble in chloroform.
Thimerosal: Light cream-colored, crystalline powder, having a slight characteristic odor. Is affected by light. The pH of a solution (1 in 100) is about 6.7. Freely soluble in water; soluble in alcohol; practically insoluble in ether. NF category: Antimicrobial preservative.
Thimerosal Topical Solution: Clear liquid, having a slight characteristic odor. Is affected by light.
Thimerosal Tincture: Transparent, mobile liquid, having the characteristic odor of alcohol and acetone. Is affected by light.
Thioguanine: Pale yellow, odorless or practically odorless, crystalline powder. Insoluble in water, in alcohol, and in chloroform; freely soluble in dilute solutions of alkali hydroxides.
Thiopental Sodium: White to off-white, crystalline powder, or yellowish-white to pale greenish-yellow, hygroscopic powder. May have a disagreeable odor. Its solutions are alkaline to litmus. Its solutions decompose on standing, and on boiling precipitation occurs. Soluble in water and in alcohol; insoluble in benzene, in absolute ether, and in solvent hexane.
Thiopental Sodium for Injection: White to off-white, crystalline powder, or yellowish-white to pale greenish-yellow, hygroscopic powder. May have a disagreeable odor. Its solutions are alkaline to litmus. Its solutions decompose on standing, and on boiling precipitation occurs.
Thioridazine: White to slightly yellow, crystalline or micronized powder, odorless or having a faint odor. Practically insoluble in water; freely soluble in dehydrated alcohol and in ether; very soluble in chloroform.
Thioridazine Hydrochloride: White to slightly yellow, granular powder, having a faint odor and a very bitter taste. Freely soluble in water, in methanol, and in chloroform; insoluble in ether.
Thiostrepton: White to off-white, crystalline solid. Practically insoluble in water, in the lower alcohols, in nonpolar organic solvents, and in dilute aqueous acids or alkali; soluble in glacial acetic acid, in chloroform, in dimethylformamide, in dimethyl sulfoxide, in dioxane, and in pyridine.
Thiotepa: Fine, white, crystalline flakes, having a faint odor. Freely soluble in water, in alcohol, in chloroform, and in ether.
Thiotepa for Injection: White powder.
Thiothixene: White to tan, practically odorless crystals. Is affected by light. Practically insoluble in water; very soluble in chloroform; slightly soluble in methanol and in acetone.
Thiothixene Hydrochloride: White, or practically white, crystalline powder, having a slight odor. Is affected by light. Soluble in water; slightly soluble in chloroform; practically insoluble in benzene, in acetone, and in ether.
Threonine: White, odorless crystals, having a slightly sweet taste. Freely soluble in water; insoluble in absolute alcohol, in ether, and in chloroform.
Thrombin: White to grayish, amorphous substance dried from the frozen state.
Thymol: Colorless, often large, crystals, or white, crystalline powder, having an aromatic, thyme-like odor and a pungent taste. Is affected by light. Its alcohol solution is neutral to litmus. Very slightly soluble in water; freely soluble in alcohol, in chloroform, in ether, and in olive oil; soluble in glacial acetic acid and in fixed and volatile oils. NF category: Antimicrobial preservative; flavors and perfumes.
Thyroid: Yellowish to buff-colored, amorphous powder, having a slight, characteristic, meat-like odor and a saline taste.
Tiagabine Hydrochloride: White to off-white powder. Very slightly soluble in chloroform; sparingly soluble in water; practically insoluble in n-heptane.
Ticarcillin Disodium: White to pale yellow powder, or white to pale yellow solid. Freely soluble in water.
Tiletamine Hydrochloride: White to off-white, crystalline powder. Freely soluble in water and in 0.1 N hydrochloric acid; soluble in methanol; slightly soluble in chloroform; practically insoluble in ether.
Tilmicosin: White to off-white, amorphous solid. Slightly soluble in water and in n-hexane.
Timolol Maleate: White to practically white, odorless or practically odorless powder. Soluble in water, in alcohol, and in methanol; sparingly soluble in chloroform and in propylene glycol; insoluble in ether and in cyclohexane.
Tinidazole: Almost white or pale yellow, crystalline powder. Soluble in acetone and in methylene chloride; sparingly soluble in methanol; practically insoluble in water.
Titanium Dioxide: White, odorless, tasteless powder. Its 1 in 10 suspension in water is neutral to litmus. Insoluble in water, in hydrochloric acid, in nitric acid, and in 2 N sulfuric acid. Dissolves in hydrofluoric acid and in hot sulfuric acid. Is rendered soluble by fusion with potassium bisulfate or with alkali carbonates or hydroxides. NF category: Coating agent.
Tobramycin: White to off-white, hygroscopic powder. Freely soluble in water; very slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Tobramycin Sulfate Injection: Clear, colorless solution.
Tocainide Hydrochloride: Fine, white, odorless powder. Freely soluble in water and in alcohol; practically insoluble in chloroform and in ether.
Tocopherol: Clear, colorless to yellow, yellowish-brown, or greenish-yellow, viscous oil. Is odorless. Soluble in oils, in fats, in acetone, in alcohol, in chloroform, in ether, and in alcohol; insoluble in water. NF category: Antioxidant.
Tocopherols Excipient: Brownish-red to red, clear, viscous oil, having a mild, characteristic odor and taste. May show a slight separation of waxlike constituents in microcrystalline form. Oxidizes and darkens slowly in air and on exposure to light, particularly in alkaline media. Insoluble in water; soluble in alcohol; miscible with acetone, with chloroform, with ether, and with vegetable oils. NF category: Antioxidant.
Tolazamide: White to off-white, crystalline powder, odorless or having a slight odor. Melts with decomposition in the approximate range of 161 to 173. Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in alcohol.
Tolazoline Hydrochloride: White to off-white, crystalline powder. Its solutions are slightly acid to litmus. Freely soluble in water and in alcohol.
Tolbutamide: White, or practically white, crystalline powder. Is slightly bitter and practically odorless. Practically insoluble in water; soluble in alcohol and in chloroform.
Tolbutamide Sodium: White to off-white, practically odorless, crystalline powder, having a slightly bitter taste. Freely soluble in water; soluble in alcohol and in chloroform; very slightly soluble in ether.
Tolcapone: Yellow, fine powder or fine powder with lumps. Freely soluble in acetone and in tetrahydrofuran; soluble in methanol and in ethyl acetate; sparingly soluble in chloroform and in dichloromethane; insoluble in water and in n-hexane.
Tolmetin Sodium: Light yellow to light orange, crystalline powder. Freely soluble in water and in methanol; slightly soluble in alcohol; very slightly soluble in chloroform.
Tolnaftate: White to creamy white, fine powder, having a slight odor. Practically insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in ether; slightly soluble in alcohol.
Tolu Balsam: Brown or yellowish-brown, plastic solid, transparent in thin layers and brittle when old, dried, or exposed to cold temperatures. Has a pleasant, aromatic odor resembling that of vanilla, and a mild, aromatic taste. Practically insoluble in water and in solvent hexane; soluble in alcohol, in chloroform, and in ether, sometimes with slight residue or turbidity. NF category: Flavors and perfumes.
Torsemide: White to off-white, crystalline powder. Slightly soluble in 0.1 N sodium hydroxide, in 0.1 N hydrochloric acid, in alcohol, and in methanol; very slightly soluble in acetone and in chloroform; practically insoluble in water and in ether.
Tragacanth: Is odorless, and has an insipid, mucilaginous taste. NF category: Suspending and/or viscosity-increasing agent.
Trazodone Hydrochloride: White to off-white, crystalline powder. Sparingly soluble in chloroform and in water. Melts between 231 and 234 when the melting point determination is carried out in an evacuated capillary tube; otherwise melts with decomposition over a broad range below 230.
Tretinoin: Yellow to light-orange, crystalline powder. Insoluble in water; slightly soluble in alcohol and in chloroform.
Triacetin: Colorless, somewhat oily liquid having a slight, fatty odor and a bitter taste. Soluble in water; slightly soluble in carbon disulfide. Miscible with alcohol, with ether, and with chloroform. NF category: Plasticizer.
Triamcinolone: White or practically white, odorless, crystalline powder. Very slightly soluble in water, in chloroform, and in ether; slightly soluble in alcohol and in methanol.
Triamcinolone Acetonide: White to cream-colored, crystalline powder, having not more than a slight odor. Practically insoluble in water; sparingly soluble in dehydrated alcohol, in chloroform, and in methanol.
Triamcinolone Diacetate: Fine, white to off-white, crystalline powder, having not more than a slight odor. Practically insoluble in water; soluble in chloroform; sparingly soluble in alcohol and in methanol; slightly soluble in ether.
Triamcinolone Hexacetonide: White to cream-colored powder. Practically insoluble in water; soluble in chloroform; slightly soluble in methanol.
Triamterene: Yellow, odorless, crystalline powder. Practically insoluble in water, in benzene, in chloroform, in ether, and in dilute alkali hydroxides; soluble in formic acid; sparingly soluble in methoxyethanol; very slightly soluble in acetic acid, in alcohol, and in dilute mineral acids.
Triazolam: White to off-white, practically odorless, crystalline powder. Soluble in chloroform; slightly soluble in alcohol; practically insoluble in ether and in water.
Tributyl Citrate: Clear, practically colorless, oily liquid. Insoluble in water; freely soluble in alcohol, in isopropyl alcohol, in acetone, and in toluene. NF category: Plasticizer.
Trichlorfon: White crystalline powder. Freely soluble in acetone, in alcohol, in benzene, in chloroform, in ether, and in water; very soluble in methylene chloride; very slightly soluble in hexane and in pentane. Decomposed by alkali. Melts at about 78 with decomposition.
Trichlormethiazide: White or practically white, crystalline powder. Is odorless, or has a slight characteristic odor. Melts at about 274, with decomposition. Very slightly soluble in water, in ether, and in chloroform; freely soluble in acetone; soluble in methanol; sparingly soluble in alcohol.
Trichloromonofluoromethane: Clear, colorless gas, having a faint, ethereal odor. Its vapor pressure at 25 is about 796 mm of mercury (1 psig). NF category: Aerosol propellant.
Triclosan: Fine, whitish, crystalline powder. Melts at about 57. Practically insoluble in water; soluble in methanol, in alcohol, and in acetone; slightly soluble in hexane.
Trientine Hydrochloride: White to pale yellow, crystalline powder. Melts at about 117. Insoluble in chloroform and in ether; slightly soluble in alcohol; soluble in methanol; freely soluble in water.
Triethyl Citrate: Practically colorless, oily liquid. Soluble in water; miscible with alcohol and with ether. NF category: Plasticizer.
Trifluoperazine Hydrochloride: White to pale yellow, crystalline powder. Is practically odorless, and has a bitter taste. Melts at about 242, with decomposition. Freely soluble in water; soluble in alcohol; sparingly soluble in chloroform; insoluble in ether and in benzene.
Triflupromazine: Viscous, light amber-colored, oily liquid, which crystallizes on prolonged standing into large, irregular crystals. Practically insoluble in water.
Triflupromazine Hydrochloride: White to pale tan, crystalline powder, having a slight, characteristic odor. Melts between 170 and 178. Soluble in water, in alcohol, and in acetone; insoluble in ether.
Trifluridine: Odorless, white powder appearing under the microscope as rodlike crystals; melts at 175, with sublimation.
Medium-Chain Triglycerides: Colorless or slightly yellowish, oily liquid. Practically insoluble in water; miscible with alcohol, with methylene chloride, with hexane, and with fatty oils.
Trihexyphenidyl Hydrochloride: White or slightly off-white, crystalline powder, having not more than a very faint odor. Melts at about 250. Slightly soluble in water; soluble in alcohol and in chloroform.
Trimeprazine Tartrate: White to off-white, odorless, crystalline powder. Freely soluble in water and in chloroform; soluble in alcohol; very slightly soluble in ether and in benzene.
Trimethobenzamide Hydrochloride: White, crystalline powder having a slight phenolic odor. Soluble in water and in warm alcohol; insoluble in ether and in benzene.
Trimethoprim: White to cream-colored, odorless crystals, or crystalline powder. Very slightly soluble in water; soluble in benzyl alcohol; sparingly soluble in chloroform and in methanol; slightly soluble in alcohol and in acetone; practically insoluble in ether and in carbon tetrachloride.
Trimethoprim Sulfate: White to off-white, crystalline powder. Soluble in water, in alcohol, in dilute mineral acids, and in fixed alkalies.
Trioxsalen: White to off-white or grayish, odorless, crystalline solid. Melts at about 230. Practically insoluble in water; sparingly soluble in chloroform; slightly soluble in alcohol.
Tripelennamine Hydrochloride: White, crystalline powder. Slowly darkens on exposure to light. Its solutions are practically neutral to litmus. Freely soluble in water, in alcohol, and in chloroform; slightly soluble in acetone; insoluble in benzene, in ether, and in ethyl acetate.
Triprolidine Hydrochloride: White, crystalline powder, having no more than a slight, but unpleasant, odor. Its solutions are alkaline to litmus, and it melts at about 115. Soluble in water, in alcohol, and in chloroform; insoluble in ether.
Trolamine: Colorless to pale yellow, viscous, hygroscopic liquid having a slight, ammoniacal odor. Miscible with water and with alcohol. Soluble in chloroform. NF category: Alkalizing agent; emulsifying and/or solubilizing agent.
Troleandomycin: White, odorless, crystalline powder. Freely soluble in alcohol; soluble in chloroform; slightly soluble in ether and in water.
Tromethamine: White, crystalline powder, having a slight, characteristic odor. Freely soluble in water and in low molecular weight aliphatic alcohols; practically insoluble in chloroform, in benzene, and in carbon tetrachloride.
Tropicamide: White or practically white, crystalline powder, odorless or having not more than a slight odor. Slightly soluble in water; freely soluble in chloroform and in solutions of strong acids.
Crystallized Trypsin: White to yellowish white, odorless, crystalline or amorphous powder.
Tryptophan: White to slightly yellowish-white crystals or crystalline powder, having a slightly bitter taste. Soluble in hot alcohol and in dilute hydrochloric acid.
Tuberculin: Old Tuberculin is a clear, brownish liquid, which is readily miscible with water and has a characteristic odor. Purified Protein Derivative (PPD) of Tuberculin is a very slightly opalescent, colorless solution. Old Tuberculin and PPD concentrates contain 50% of glycerin for use with various application devices. Old Tuberculin and PPD are also dried on the tines of multiple-puncture devices.
Tubocurarine Chloride: White or yellowish-white to grayish-white, crystalline powder. Melts at about 270, with decomposition. Soluble in water; sparingly soluble in alcohol.
Tylosin: White to buff-colored powder. Freely soluble in methanol; soluble in alcohol, in amyl acetate, in chloroform, and in dilute mineral acids; slightly soluble in water.
Tyloxapol: Viscous, amber liquid, having a slight, aromatic odor. May exhibit a slight turbidity. Slowly but freely miscible with water. Soluble in glacial acetic acid, in benzene, in toluene, in carbon tetrachloride, in chloroform, and in carbon disulfide. NF category: Wetting and/or solubilizing agent.
Tyrosine: White, odorless, tasteless crystals or crystalline powder. Very slightly soluble in water; insoluble in alcohol and in ether.