U.S. PHARMACOPEIA

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Dactinomycin: Bright red, crystalline powder. Is somewhat hygroscopic and is affected by light and by heat. Soluble in water at 10 and slightly soluble in water at 37; freely soluble in alcohol; very slightly soluble in ether.
Danazol: White to pale yellow, crystalline powder. Melts at about 225, with some decomposition. Practically insoluble or insoluble in water and in hexane; freely soluble in chloroform; soluble in acetone; sparingly soluble in alcohol and in benzene; slightly soluble in ether.
Dapsone: White or creamy white, crystalline powder. Is odorless and has a slightly bitter taste. Very slightly soluble in water; freely soluble in alcohol; soluble in acetone and in dilute mineral acids.
Daunorubicin Hydrochloride: Orange-red, crystalline, hygroscopic powder. Freely soluble in water and in methanol; slightly soluble in alcohol; very slightly soluble in chloroform; practically insoluble in acetone.
Deferoxamine Mesylate: White to off-white powder. Freely soluble in water; slightly soluble in methanol.
Dehydrocholic Acid: White, fluffy, odorless powder, having a bitter taste. Practically insoluble in water; soluble in glacial acetic acid and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol and in ether; sparingly soluble in chloroform (the solutions in alcohol and in chloroform usually are slightly turbid).
Demecarium Bromide: White or slightly yellow, slightly hygroscopic, crystalline powder. Freely soluble in water and in alcohol; soluble in ether; sparingly soluble in acetone.
Demeclocycline: Yellow, crystalline, odorless powder, having a bitter taste. Sparingly soluble in water; soluble in alcohol. Dissolves readily in 3 N hydrochloric acid and in alkaline solutions.
Demeclocycline Hydrochloride: Yellow, crystalline, odorless powder, having a bitter taste. Sparingly soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in acetone and in chloroform.
Denatonium Benzoate: Freely soluble in water and in alcohol; very soluble in chloroform and in methanol; very slightly soluble in ether. NF category: Alcohol denaturant.
Desipramine Hydrochloride: White to off-white, crystalline powder. Melts at about 213. Soluble in water and in alcohol; freely soluble in methanol and in chloroform; insoluble in ether.
Desoximetasone: White to practically white, odorless, crystalline powder. Insoluble in water; freely soluble in alcohol, in acetone, and in chloroform.
Desoxycorticosterone Acetate: White or creamy white, crystalline powder. Is odorless, and is stable in air. Practically insoluble in water; sparingly soluble in alcohol, in acetone, and in dioxane; slightly soluble in vegetable oils.
Dexamethasone: White to practically white, odorless, crystalline powder. Is stable in air. Melts at about 250, with some decomposition. Practically insoluble in water; sparingly soluble in acetone, in alcohol, in dioxane, and in methanol; slightly soluble in chloroform; very slightly soluble in ether.
Dexamethasone Acetate: Clear, white to off-white, odorless powder. Practically insoluble in water; freely soluble in methanol, in acetone, and in dioxane.
Dexamethasone Sodium Phosphate: White or slightly yellow, crystalline powder. Is odorless or has a slight odor of alcohol, and is exceedingly hygroscopic. Freely soluble in water; slightly soluble in alcohol; very slightly soluble in dioxane; insoluble in chloroform and in ether.
Dexbrompheniramine Maleate: White, odorless, crystalline powder. Exists in two polymorphic forms, one melting between 106 and 107 and the other between 112 and 113. Mixtures of the forms may melt between 105 and 113. The pH of a solution (1 in 100) is about 5. Freely soluble in water; soluble in alcohol and in chloroform.
Dexchlorpheniramine Maleate: White, odorless, crystalline powder. Freely soluble in water; soluble in alcohol and in chloroform; slightly soluble in benzene and in ether.
Dexpanthenol: Clear, viscous, somewhat hygroscopic liquid, having a slight, characteristic odor. Some crystallization may occur on standing. Freely soluble in water, in alcohol, in methanol, and in propylene glycol; soluble in chloroform and in ether; slightly soluble in glycerin.
Dextran 1: A white to off-white powder. Is hygroscopic. Very soluble in water; sparingly soluble in alcohol.
Dextrates: Free-flowing, porous, white, odorless, spherical granules consisting of aggregates of microcrystals, having a sweet taste and producing a cooling sensation in the mouth. May be compressed directly into self-binding tablets. Freely soluble in water (heating increases its solubility in water); soluble in dilute acids and alkalies and in basic organic solvents such as pyridine; insoluble in the common organic solvents. NF category: Sweetening agent; tablet and/or capsule diluent.
Dextrin: Free-flowing, white, yellow, or brown powder. Its solubility in water varies; it is usually very soluble, but often contains an insoluble portion. NF category: Tablet binder; tablet and/or capsule diluent.
Dextroamphetamine Sulfate: White, odorless, crystalline powder. Soluble in water; slightly soluble in alcohol; insoluble in ether.
Dextromethorphan: Practically white to slightly yellow, odorless, crystalline powder. Eleven mg of Dextromethorphan is equivalent to 15 mg of dextromethorphan hydrobromide monohydrate. Practically insoluble in water; freely soluble in chloroform.
Dextromethorphan Hydrobromide: Practically white crystals or crystalline powder, having a faint odor. Melts at about 126, with decomposition. Sparingly soluble in water; freely soluble in alcohol and in chloroform; insoluble in ether.
Dextrose: Colorless crystals or white, crystalline or granular powder. Is odorless, and has a sweet taste. Freely soluble in water; very soluble in boiling water; soluble in boiling alcohol; slightly soluble in alcohol. NF category: Sweetening agent; tonicity agent; vehicle (flavored and/or sweetened).
Dextrose Excipient: Colorless crystals or white, crystalline or granular powder. Is odorless and sweet-tasting. Freely soluble in water; very soluble in boiling water; sparingly soluble in boiling alcohol; slightly soluble in alcohol. NF category: Sweetening agent; tablet and/or capsule diluent.
Diacetylated Monoglycerides: Clear liquid. Very soluble in 80% (w/w) aqueous alcohol, in vegetable oils, and in mineral oils; sparingly soluble in 70% alcohol. NF category: Plasticizer.
Diatrizoate Meglumine: White, odorless powder. Freely soluble in water.
Diatrizoate Meglumine Injection: Clear, colorless to pale yellow, slightly viscous liquid.
Diatrizoate Meglumine and Diatrizoate Sodium Injection: Clear, colorless to pale yellow, slightly viscous liquid. May crystallize at room temperature or below.
Diatrizoate Sodium: White, odorless powder. Soluble in water; slightly soluble in alcohol; practically insoluble in acetone and in ether.
Diatrizoate Sodium Injection: Clear, colorless to pale yellow, slightly viscous liquid.
Diatrizoate Sodium Solution: Clear, pale yellow to light brown liquid.
Diatrizoic Acid: White, odorless powder. Very slightly soluble in water and in alcohol; soluble in dimethylformamide and in alkali hydroxide solutions.
Diazepam: Off-white to yellow, practically odorless, crystalline powder. Practically insoluble in water; freely soluble in chloroform; soluble in alcohol.
Diazoxide: White or cream-white crystals or crystalline powder. Practically insoluble to sparingly soluble in water and in most organic solvents; very soluble in strong alkaline solutions; freely soluble in dimethylformamide.
Dibucaine: White to off-white powder, having a slight, characteristic odor. Darkens on exposure to light. Slightly soluble in water; soluble in 1 N hydrochloric acid and in ether.
Dibucaine Hydrochloride: Colorless or white to off-white crystals or white to off-white, crystalline powder. Is odorless, is somewhat hygroscopic, and darkens on exposure to light. Its solutions have a pH of about 5.5. Freely soluble in water, in alcohol, in acetone, and in chloroform.
Dibutyl Phthalate: A clear, oily liquid, colorless or very slightly yellow. Practically insoluble in water; miscible with alcohol and with ether.
Dibutyl Sebacate: Colorless, oily liquid of very mild odor. Soluble in alcohol, in isopropyl alcohol, and in mineral oil; very slightly soluble in propylene glycol; practically insoluble in water and in glycerin. NF category: Plasticizer.
Dichloralphenazone: White, microcrystalline powder. Has a slight odor characteristic of chloral hydrate. Decomposed by dilute alkali, liberating chloroform. Freely soluble in water, in alcohol, and in chloroform; soluble in dilute acids.
Dichlorodifluoromethane: Clear, colorless gas, having a faint, ethereal odor. Its vapor pressure at 25 is about 4880 mm of mercury (80 psig). NF category: Aerosol propellant.
Dichlorotetrafluoroethane: Clear, colorless gas, having a faint, ethereal odor. Its vapor pressure at 25 is about 1620 mm of mercury (17 psig). Usually contains between 6% and 10% of its isomer, CCl2F-CF3. NF category: Aerosol propellant.
Diclofenac Sodium: White to off-white, hygroscopic, crystalline powder. Melts at about 284. Freely soluble in methanol; soluble in ethanol; sparingly soluble in water; practically insoluble in chloroform and in ether.
Dicloxacillin Sodium: White to off-white, crystalline powder. Freely soluble in water.
Dicyclomine Hydrochloride: Fine, white, crystalline powder. Is practically odorless and has a very bitter taste. Soluble in water; freely soluble in alcohol and in chloroform; very slightly soluble in ether.
Dicyclomine Hydrochloride Injection: Colorless solution, which may have the odor of a preservative.
Dienestrol: Colorless, white or practically white, needle-like crystals, or white or practically white, crystalline powder. Is odorless. Practically insoluble in water; soluble in alcohol, in acetone, in ether, in methanol, in propylene glycol, and in solutions of alkali hydroxides; slightly soluble in chloroform and in fatty oils.
Diethanolamine: White or clear, colorless crystals, deliquescing in moist air; or colorless liquid. Miscible with water, with alcohol, with acetone, with chloroform, and with glycerin. Slightly soluble to insoluble in benzene, in ether, and in petroleum ether. NF category: Alkalizing agent; emulsifying and/or solubilizing agent.
Diethylcarbamazine Citrate: White, crystalline powder. Melts at about 136, with decomposition. Is odorless or has a slight odor; is slightly hygroscopic. Very soluble in water; sparingly soluble in alcohol; practically insoluble in acetone, in chloroform, and in ether.
Diethylene Glycol Monoethyl Ether: Clear, colorless liquid. Is hygroscopic. Miscible with water, with acetone, and with alcohol; partially miscible with vegetable oils; immiscible with mineral oils. Specific gravity about 0.991. NF category: Ointment base; solvent.
Diethylene Glycol Stearates: White or almost white, waxy solid. Soluble in acetone and in hot alcohol; practically insoluble in water. NF category: Emulsifying and/or solubilizing agent.
Diethyl Phthalate: Colorless, practically odorless, oily liquid. Insoluble in water. Miscible with alcohol, with ether, and with other usual organic solvents. NF category: Plasticizer.
Diethylpropion Hydrochloride: White to off-white, fine crystalline powder. Is odorless, or has a slight characteristic odor. It melts at about 175, with decomposition. Freely soluble in water, in chloroform, and in alcohol; practically insoluble in ether.
Diethylstilbestrol: White, odorless, crystalline powder. Practically insoluble in water; soluble in alcohol, in chloroform, in ether, in fatty oils, and in dilute alkali hydroxides.
Diethylstilbestrol Diphosphate: Off-white, odorless, crystalline powder. Sparingly soluble in water; soluble in alcohol and in dilute alkali.
Diethylstilbestrol Diphosphate Injection: Colorless to light, straw-colored liquid.
Diethyltoluamide: Colorless liquid, having a faint, pleasant odor. Boils at about 111 under a pressure of 1 mm of mercury. Practically insoluble in water and in glycerin. Miscible with alcohol, with isopropyl alcohol, with ether, with chloroform, and with carbon disulfide.
Diflorasone Diacetate: White to pale yellow, crystalline powder. Insoluble in water; soluble in methanol and in acetone; sparingly soluble in ethyl acetate; slightly soluble in toluene; very slightly soluble in ether.
Diflunisal: White to off-white, practically odorless powder. Freely soluble in alcohol and in methanol; soluble in acetone and in ethyl acetate; slightly soluble in chloroform, in carbon tetrachloride, and in methylene chloride; insoluble in hexane and in water.
Digitoxin: White or pale buff, odorless, microcrystalline powder. Practically insoluble in water; sparingly soluble in chloroform; slightly soluble in alcohol; very slightly soluble in ether.
Digoxin: Clear to white, odorless crystals or white, odorless crystalline powder. Practically insoluble in water and in ether; freely soluble in pyridine; slightly soluble in diluted alcohol and in chloroform.
Dihydroergotamine Mesylate: White to slightly yellowish powder, or off-white to faintly red powder, having a faint odor. Slightly soluble in water and in chloroform; soluble in alcohol.
Dihydrostreptomycin Sulfate: White or almost white, amorphous or crystalline powder. Amorphous form is hygroscopic. Freely soluble in water; practically insoluble in acetone, in chloroform, and in methanol.
Dihydrotachysterol: Colorless or white, odorless crystals, or white, odorless, crystalline powder. Practically insoluble in water; soluble in alcohol; freely soluble in ether and in chloroform; sparingly soluble in vegetable oils.
Dihydroxyacetone: White to off-white crystalline powder. The monomeric form is freely soluble in water, in alcohol, and in ether. The dimeric form is freely soluble in water; soluble in alcohol; and sparingly soluble in ether.
Dihydroxyaluminum Aminoacetate: White, odorless powder having a faintly sweet taste. Insoluble in water and in organic solvents; soluble in dilute mineral acids and in solutions of fixed alkalies.
Dihydroxyaluminum Aminoacetate Magma: White, viscous suspension, from which small amounts of water may separate on standing.
Dihydroxyaluminum Sodium Carbonate: Fine, white, odorless powder. Practically insoluble in water and in organic solvents; soluble in dilute mineral acids with the evolution of carbon dioxide.
Diloxanide Furoate: White or almost white, crystalline powder. Freely soluble in chloroform; slightly soluble in alcohol and in ether; very slightly soluble in water.
Diltiazem Hydrochloride: White, odorless, crystalline powder or small crystals. Freely soluble in chloroform, in formic acid, in methanol, and in water; sparingly soluble in dehydrated alcohol; insoluble in ether. Melts at about 210, with decomposition.
Dimenhydrinate: White, crystalline, odorless powder. Slightly soluble in water; freely soluble in alcohol and in chloroform; sparingly soluble in ether.
Dimercaprol: Colorless or practically colorless liquid, having a disagreeable, mercaptan-like odor. Soluble in water, in alcohol, in benzyl benzoate, and in methanol.
Dimercaprol Injection: Yellow, viscous solution having a pungent, disagreeable odor. Specific gravity is about 0.978.
Dimethicone: A clear, colorless, and odorless liquid. Soluble in chlorinated hydrocarbons, in benzene, in toluene, in xylene, in n-hexane, in petroleum spirits, in ether, and in amyl acetate; very slightly soluble in isopropyl alcohol; insoluble in water, in methanol, in alcohol, and in acetone. NF category: Antifoaming agent; water repelling agent.
Dimethyl Sulfoxide: Clear, colorless, odorless, hygroscopic liquid. Melts at about 18.4. Boils at about 189. Soluble in water; practically insoluble in acetone, in alcohol, in benzene, in chloroform, and in ether.
Dinoprostone: White to off-white, crystalline powder. Freely soluble in acetone, in alcohol, in ether, in ethyl acetate, in isopropyl alcohol, in methanol, and in methylene chloride; soluble in toluene and in diisopropyl ether; practically insoluble in hexanes.
Dinoprost Tromethamine: White to off-white, crystalline powder. Very soluble in water; freely soluble in dimethylformamide; soluble in methanol; slightly soluble in chloroform.
Dioxybenzone: Yellow powder. Practically insoluble in water; freely soluble in alcohol and in toluene.
Diphenhydramine Hydrochloride: White, odorless, crystalline powder. Slowly darkens on exposure to light. Its solutions are practically neutral to litmus. Freely soluble in water, in alcohol, and in chloroform; sparingly soluble in acetone; very slightly soluble in benzene and in ether.
Diphenoxylate Hydrochloride: White, odorless, crystalline powder. Its saturated solution has a pH of about 3.3. Slightly soluble in water and in isopropanol; freely soluble in chloroform; soluble in methanol; sparingly soluble in alcohol and in acetone; practically insoluble in ether and in solvent hexane.
Diphtheria Toxin for Schick Test: Transparent liquid.
Diphtheria and Tetanus Toxoids Adsorbed: Turbid, and white, slightly gray, or slightly pink suspension, free from evident clumps after shaking.
Dipivefrin Hydrochloride: White, crystalline powder or small crystals, having a faint odor. Very soluble in water.
Dipyridamole: Intensely yellow, crystalline powder or needles. Very soluble in methanol, in alcohol, and in chloroform; slightly soluble in water; very slightly soluble in acetone and in ethyl acetate.
Dirithromycin: White or practically white powder. Very slightly soluble in water; very soluble in methanol and in methylene chloride.
Disopyramide Phosphate: White or practically white, odorless powder. Melts at about 205, with decomposition. Freely soluble in water; slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Disulfiram: White to off-white, odorless, crystalline powder. Very slightly soluble in water; soluble in acetone, in alcohol, in carbon disulfide, and in chloroform.
Dobutamine Hydrochloride: White to practically white, crystalline powder. Sparingly soluble in water and in methanol; soluble in alcohol and in pyridine.
Docusate Calcium: White, amorphous solid, having the characteristic odor of octyl alcohol. It is free of the odor of other solvents. Very slightly soluble in water; very soluble in alcohol, in polyethylene glycol 400, and in corn oil.
Docusate Potassium: White, amorphous solid, having a characteristic odor suggestive of octyl alcohol. Sparingly soluble in water; very soluble in solvent hexane; soluble in alcohol and in glycerin.
Docusate Sodium: White, wax-like, plastic solid, having a characteristic odor suggestive of octyl alcohol, but no odor of other solvents. Sparingly soluble in water; very soluble in solvent hexane; freely soluble in alcohol and in glycerin. NF category: Wetting and/or solubilizing agent.
Dolasetron Mesylate: White to off-white powder. Freely soluble in water and in propylene glycol; slightly soluble in alcohol and in saline TS.
Dopamine Hydrochloride: White to off-white, crystalline powder. May have a slight odor of hydrochloric acid. Melts at about 240, with decomposition. Freely soluble in water and in aqueous solutions of alkali hydroxides; soluble in methanol; insoluble in ether and in chloroform.
Dorzolamide Hydrochloride: White to off-white, crystalline powder. Soluble in water.
Doxapram Hydrochloride: White to off-white, odorless, crystalline powder. Melts at about 220. Soluble in water and in chloroform; sparingly soluble in alcohol; practically insoluble in ether.
Doxorubicin Hydrochloride: Red-orange, hygroscopic, crystalline powder. Soluble in water, in isotonic sodium chloride solution, and in methanol; practically insoluble in chloroform, in ether, and in other organic solvents.
Doxycycline: Yellow, crystalline powder. Very slightly soluble in water; freely soluble in dilute acid and in alkali hydroxide solutions; sparingly soluble in alcohol; practically insoluble in chloroform and in ether.
Doxycycline Hyclate: Yellow, crystalline powder. Soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Doxylamine Succinate: White or creamy white powder, having a characteristic odor. Very soluble in water and in alcohol; freely soluble in chloroform; very slightly soluble in ether and in benzene.
Droperidol: White to light tan, amorphous or microcrystalline powder. Practically insoluble in water; freely soluble in chloroform; slightly soluble in alcohol and in ether. Melts at about 145.
Absorbable Dusting Powder: White, odorless powder.
Dyclonine Hydrochloride: White crystals or white crystalline powder, which may have a slight odor. Exhibits local anesthetic properties when placed upon the tongue. Soluble in water, in acetone, in alcohol, and in chloroform.
Dydrogesterone: White to pale yellow, crystalline powder. Practically insoluble in water; sparingly soluble in alcohol.
Dyphylline: White, odorless, extremely bitter, amorphous or crystalline solid. Freely soluble in water; sparingly soluble in alcohol and in chloroform; practically insoluble in ether.