Dactinomycin:
Bright red, crystalline powder. Is somewhat hygroscopic and is affected by light and by heat. Soluble in water at 10
and slightly soluble in water at 37
; freely soluble in alcohol; very slightly soluble in ether.
Danazol:
White to pale yellow, crystalline powder. Melts at about 225
, with some decomposition. Practically insoluble or insoluble in water and in hexane; freely soluble in chloroform; soluble in acetone; sparingly soluble in alcohol and in benzene; slightly soluble in ether.
Dapsone:
White or creamy white, crystalline powder. Is odorless and has a slightly bitter taste. Very slightly soluble in water; freely soluble in alcohol; soluble in acetone and in dilute mineral acids.
Daunorubicin Hydrochloride:
Orange-red, crystalline, hygroscopic powder. Freely soluble in water and in methanol; slightly soluble in alcohol; very slightly soluble in chloroform; practically insoluble in acetone.
Deferoxamine Mesylate:
White to off-white powder. Freely soluble in water; slightly soluble in methanol.
Dehydrocholic Acid:
White, fluffy, odorless powder, having a bitter taste. Practically insoluble in water; soluble in glacial acetic acid and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol and in ether; sparingly soluble in chloroform (the solutions in alcohol and in chloroform usually are slightly turbid).
Demecarium Bromide:
White or slightly yellow, slightly hygroscopic, crystalline powder. Freely soluble in water and in alcohol; soluble in ether; sparingly soluble in acetone.
Demeclocycline:
Yellow, crystalline, odorless powder, having a bitter taste. Sparingly soluble in water; soluble in alcohol. Dissolves readily in 3 N hydrochloric acid and in alkaline solutions.
Demeclocycline Hydrochloride:
Yellow, crystalline, odorless powder, having a bitter taste. Sparingly soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in acetone and in chloroform.
Denatonium Benzoate:
Freely soluble in water and in alcohol; very soluble in chloroform and in methanol; very slightly soluble in ether.
NF category: Alcohol denaturant.
Desipramine Hydrochloride:
White to off-white, crystalline powder. Melts at about 213
. Soluble in water and in alcohol; freely soluble in methanol and in chloroform; insoluble in ether.
Desoximetasone:
White to practically white, odorless, crystalline powder. Insoluble in water; freely soluble in alcohol, in acetone, and in chloroform.
Desoxycorticosterone Acetate:
White or creamy white, crystalline powder. Is odorless, and is stable in air. Practically insoluble in water; sparingly soluble in alcohol, in acetone, and in dioxane; slightly soluble in vegetable oils.
Dexamethasone:
White to practically white, odorless, crystalline powder. Is stable in air. Melts at about 250
, with some decomposition. Practically insoluble in water; sparingly soluble in acetone, in alcohol, in dioxane, and in methanol; slightly soluble in chloroform; very slightly soluble in ether.
Dexamethasone Acetate:
Clear, white to off-white, odorless powder. Practically insoluble in water; freely soluble in methanol, in acetone, and in dioxane.
Dexamethasone Sodium Phosphate:
White or slightly yellow, crystalline powder. Is odorless or has a slight odor of alcohol, and is exceedingly hygroscopic. Freely soluble in water; slightly soluble in alcohol; very slightly soluble in dioxane; insoluble in chloroform and in ether.
Dexbrompheniramine Maleate:
White, odorless, crystalline powder. Exists in two polymorphic forms, one melting between 106
and 107
and the other between 112
and 113
. Mixtures of the forms may melt between 105
and 113
. The pH of a solution (1 in 100) is about 5. Freely soluble in water; soluble in alcohol and in chloroform.
Dexchlorpheniramine Maleate:
White, odorless, crystalline powder. Freely soluble in water; soluble in alcohol and in chloroform; slightly soluble in benzene and in ether.
Dexpanthenol:
Clear, viscous, somewhat hygroscopic liquid, having a slight, characteristic odor. Some crystallization may occur on standing. Freely soluble in water, in alcohol, in methanol, and in propylene glycol; soluble in chloroform and in ether; slightly soluble in glycerin.
Dextran 1:
A white to off-white powder. Is hygroscopic. Very soluble in water; sparingly soluble in alcohol.
Dextrates:
Free-flowing, porous, white, odorless, spherical granules consisting of aggregates of microcrystals, having a sweet taste and producing a cooling sensation in the mouth. May be compressed directly into self-binding tablets. Freely soluble in water (heating increases its solubility in water); soluble in dilute acids and alkalies and in basic organic solvents such as pyridine; insoluble in the common organic solvents.
NF category: Sweetening agent; tablet and/or capsule diluent.
Dextrin:
Free-flowing, white, yellow, or brown powder. Its solubility in water varies; it is usually very soluble, but often contains an insoluble portion.
NF category: Tablet binder; tablet and/or capsule diluent.
Dextroamphetamine Sulfate:
White, odorless, crystalline powder. Soluble in water; slightly soluble in alcohol; insoluble in ether.
Dextromethorphan:
Practically white to slightly yellow, odorless, crystalline powder. Eleven mg of Dextromethorphan is equivalent to 15 mg of dextromethorphan hydrobromide monohydrate. Practically insoluble in water; freely soluble in chloroform.
Dextromethorphan Hydrobromide:
Practically white crystals or crystalline powder, having a faint odor. Melts at about 126
, with decomposition. Sparingly soluble in water; freely soluble in alcohol and in chloroform; insoluble in ether.
Dextrose:
Colorless crystals or white, crystalline or granular powder. Is odorless, and has a sweet taste. Freely soluble in water; very soluble in boiling water; soluble in boiling alcohol; slightly soluble in alcohol.
NF category: Sweetening agent; tonicity agent; vehicle (flavored and/or sweetened).
Dextrose Excipient:
Colorless crystals or white, crystalline or granular powder. Is odorless and sweet-tasting. Freely soluble in water; very soluble in boiling water; sparingly soluble in boiling alcohol; slightly soluble in alcohol.
NF category: Sweetening agent; tablet and/or capsule diluent.
Diacetylated Monoglycerides:
Clear liquid. Very soluble in 80% (w/w) aqueous alcohol, in vegetable oils, and in mineral oils; sparingly soluble in 70% alcohol.
NF category: Plasticizer.
Diatrizoate Meglumine:
White, odorless powder. Freely soluble in water.
Diatrizoate Meglumine Injection:
Clear, colorless to pale yellow, slightly viscous liquid.
Diatrizoate Meglumine and Diatrizoate Sodium Injection:
Clear, colorless to pale yellow, slightly viscous liquid. May crystallize at room temperature or below.
Diatrizoate Sodium:
White, odorless powder. Soluble in water; slightly soluble in alcohol; practically insoluble in acetone and in ether.
Diatrizoate Sodium Injection:
Clear, colorless to pale yellow, slightly viscous liquid.
Diatrizoate Sodium Solution:
Clear, pale yellow to light brown liquid.
Diatrizoic Acid:
White, odorless powder. Very slightly soluble in water and in alcohol; soluble in dimethylformamide and in alkali hydroxide solutions.
Diazepam:
Off-white to yellow, practically odorless, crystalline powder. Practically insoluble in water; freely soluble in chloroform; soluble in alcohol.
Diazoxide:
White or cream-white crystals or crystalline powder. Practically insoluble to sparingly soluble in water and in most organic solvents; very soluble in strong alkaline solutions; freely soluble in dimethylformamide.
Dibucaine:
White to off-white powder, having a slight, characteristic odor. Darkens on exposure to light. Slightly soluble in water; soluble in 1 N hydrochloric acid and in ether.
Dibucaine Hydrochloride:
Colorless or white to off-white crystals or white to off-white, crystalline powder. Is odorless, is somewhat hygroscopic, and darkens on exposure to light. Its solutions have a pH of about 5.5. Freely soluble in water, in alcohol, in acetone, and in chloroform.
Dibutyl Phthalate:
A clear, oily liquid, colorless or very slightly yellow. Practically insoluble in water; miscible with alcohol and with ether.
Dibutyl Sebacate:
Colorless, oily liquid of very mild odor. Soluble in alcohol, in isopropyl alcohol, and in mineral oil; very slightly soluble in propylene glycol; practically insoluble in water and in glycerin.
NF category: Plasticizer.
Dichloralphenazone:
White, microcrystalline powder. Has a slight odor characteristic of chloral hydrate. Decomposed by dilute alkali, liberating chloroform. Freely soluble in water, in alcohol, and in chloroform; soluble in dilute acids.
Dichlorodifluoromethane:
Clear, colorless gas, having a faint, ethereal odor. Its vapor pressure at 25
is about 4880 mm of mercury (80 psig).
NF category: Aerosol propellant.
Dichlorotetrafluoroethane:
Clear, colorless gas, having a faint, ethereal odor. Its vapor pressure at 25
is about 1620 mm of mercury (17 psig). Usually contains between 6% and 10% of its isomer, CCl
2F-CF
3.
NF category: Aerosol propellant.
Diclofenac Sodium:
White to off-white, hygroscopic, crystalline powder. Melts at about 284
. Freely soluble in methanol; soluble in ethanol; sparingly soluble in water; practically insoluble in chloroform and in ether.
Dicloxacillin Sodium:
White to off-white, crystalline powder. Freely soluble in water.
Dicyclomine Hydrochloride:
Fine, white, crystalline powder. Is practically odorless and has a very bitter taste. Soluble in water; freely soluble in alcohol and in chloroform; very slightly soluble in ether.
Dicyclomine Hydrochloride Injection:
Colorless solution, which may have the odor of a preservative.
Dienestrol:
Colorless, white or practically white, needle-like crystals, or white or practically white, crystalline powder. Is odorless. Practically insoluble in water; soluble in alcohol, in acetone, in ether, in methanol, in propylene glycol, and in solutions of alkali hydroxides; slightly soluble in chloroform and in fatty oils.
Diethanolamine:
White or clear, colorless crystals, deliquescing in moist air; or colorless liquid. Miscible with water, with alcohol, with acetone, with chloroform, and with glycerin. Slightly soluble to insoluble in benzene, in ether, and in petroleum ether.
NF category: Alkalizing agent; emulsifying and/or solubilizing agent.
Diethylcarbamazine Citrate:
White, crystalline powder. Melts at about 136
, with decomposition. Is odorless or has a slight odor; is slightly hygroscopic. Very soluble in water; sparingly soluble in alcohol; practically insoluble in acetone, in chloroform, and in ether.
Diethylene Glycol Monoethyl Ether:
Clear, colorless liquid. Is hygroscopic. Miscible with water, with acetone, and with alcohol; partially miscible with vegetable oils; immiscible with mineral oils. Specific gravity about 0.991.
NF category: Ointment base; solvent.
Diethylene Glycol Stearates:
White or almost white, waxy solid. Soluble in acetone and in hot alcohol; practically insoluble in water.
NF category: Emulsifying and/or solubilizing agent.
Diethyl Phthalate:
Colorless, practically odorless, oily liquid. Insoluble in water. Miscible with alcohol, with ether, and with other usual organic solvents.
NF category: Plasticizer.
Diethylpropion Hydrochloride:
White to off-white, fine crystalline powder. Is odorless, or has a slight characteristic odor. It melts at about 175
, with decomposition. Freely soluble in water, in chloroform, and in alcohol; practically insoluble in ether.
Diethylstilbestrol:
White, odorless, crystalline powder. Practically insoluble in water; soluble in alcohol, in chloroform, in ether, in fatty oils, and in dilute alkali hydroxides.
Diethylstilbestrol Diphosphate:
Off-white, odorless, crystalline powder. Sparingly soluble in water; soluble in alcohol and in dilute alkali.
Diethylstilbestrol Diphosphate Injection:
Colorless to light, straw-colored liquid.
Diethyltoluamide:
Colorless liquid, having a faint, pleasant odor. Boils at about 111
under a pressure of 1 mm of mercury. Practically insoluble in water and in glycerin. Miscible with alcohol, with isopropyl alcohol, with ether, with chloroform, and with carbon disulfide.
Diflorasone Diacetate:
White to pale yellow, crystalline powder. Insoluble in water; soluble in methanol and in acetone; sparingly soluble in ethyl acetate; slightly soluble in toluene; very slightly soluble in ether.
Diflunisal:
White to off-white, practically odorless powder. Freely soluble in alcohol and in methanol; soluble in acetone and in ethyl acetate; slightly soluble in chloroform, in carbon tetrachloride, and in methylene chloride; insoluble in hexane and in water.
Digitoxin:
White or pale buff, odorless, microcrystalline powder. Practically insoluble in water; sparingly soluble in chloroform; slightly soluble in alcohol; very slightly soluble in ether.
Digoxin:
Clear to white, odorless crystals or white, odorless crystalline powder. Practically insoluble in water and in ether; freely soluble in pyridine; slightly soluble in diluted alcohol and in chloroform.
Dihydroergotamine Mesylate:
White to slightly yellowish powder, or off-white to faintly red powder, having a faint odor. Slightly soluble in water and in chloroform; soluble in alcohol.
Dihydrostreptomycin Sulfate:
White or almost white, amorphous or crystalline powder. Amorphous form is hygroscopic. Freely soluble in water; practically insoluble in acetone, in chloroform, and in methanol.
Dihydrotachysterol:
Colorless or white, odorless crystals, or white, odorless, crystalline powder. Practically insoluble in water; soluble in alcohol; freely soluble in ether and in chloroform; sparingly soluble in vegetable oils.
Dihydroxyacetone:
White to off-white crystalline powder. The monomeric form is freely soluble in water, in alcohol, and in ether. The dimeric form is freely soluble in water; soluble in alcohol; and sparingly soluble in ether.
Dihydroxyaluminum Aminoacetate:
White, odorless powder having a faintly sweet taste. Insoluble in water and in organic solvents; soluble in dilute mineral acids and in solutions of fixed alkalies.
Dihydroxyaluminum Aminoacetate Magma:
White, viscous suspension, from which small amounts of water may separate on standing.
Dihydroxyaluminum Sodium Carbonate:
Fine, white, odorless powder. Practically insoluble in water and in organic solvents; soluble in dilute mineral acids with the evolution of carbon dioxide.
Diloxanide Furoate:
White or almost white, crystalline powder. Freely soluble in chloroform; slightly soluble in alcohol and in ether; very slightly soluble in water.
Diltiazem Hydrochloride:
White, odorless, crystalline powder or small crystals. Freely soluble in chloroform, in formic acid, in methanol, and in water; sparingly soluble in dehydrated alcohol; insoluble in ether. Melts at about 210
, with decomposition.
Dimenhydrinate:
White, crystalline, odorless powder. Slightly soluble in water; freely soluble in alcohol and in chloroform; sparingly soluble in ether.
Dimercaprol:
Colorless or practically colorless liquid, having a disagreeable, mercaptan-like odor. Soluble in water, in alcohol, in benzyl benzoate, and in methanol.
Dimercaprol Injection:
Yellow, viscous solution having a pungent, disagreeable odor. Specific gravity is about 0.978.
Dimethicone:
A clear, colorless, and odorless liquid. Soluble in chlorinated hydrocarbons, in benzene, in toluene, in xylene, in
n-hexane, in petroleum spirits, in ether, and in amyl acetate; very slightly soluble in isopropyl alcohol; insoluble in water, in methanol, in alcohol, and in acetone.
NF category: Antifoaming agent; water repelling agent.
Dimethyl Sulfoxide:
Clear, colorless, odorless, hygroscopic liquid. Melts at about 18.4
. Boils at about 189
. Soluble in water; practically insoluble in acetone, in alcohol, in benzene, in chloroform, and in ether.
Dinoprostone:
White to off-white, crystalline powder. Freely soluble in acetone, in alcohol, in ether, in ethyl acetate, in isopropyl alcohol, in methanol, and in methylene chloride; soluble in toluene and in diisopropyl ether; practically insoluble in hexanes.
Dinoprost Tromethamine:
White to off-white, crystalline powder. Very soluble in water; freely soluble in dimethylformamide; soluble in methanol; slightly soluble in chloroform.
Dioxybenzone:
Yellow powder. Practically insoluble in water; freely soluble in alcohol and in toluene.
Diphenhydramine Hydrochloride:
White, odorless, crystalline powder. Slowly darkens on exposure to light. Its solutions are practically neutral to litmus. Freely soluble in water, in alcohol, and in chloroform; sparingly soluble in acetone; very slightly soluble in benzene and in ether.
Diphenoxylate Hydrochloride:
White, odorless, crystalline powder. Its saturated solution has a pH of about 3.3. Slightly soluble in water and in isopropanol; freely soluble in chloroform; soluble in methanol; sparingly soluble in alcohol and in acetone; practically insoluble in ether and in solvent hexane.
Diphtheria Toxin for Schick Test:
Transparent liquid.
Diphtheria and Tetanus Toxoids Adsorbed:
Turbid, and white, slightly gray, or slightly pink suspension, free from evident clumps after shaking.
Dipivefrin Hydrochloride:
White, crystalline powder or small crystals, having a faint odor. Very soluble in water.
Dipyridamole:
Intensely yellow, crystalline powder or needles. Very soluble in methanol, in alcohol, and in chloroform; slightly soluble in water; very slightly soluble in acetone and in ethyl acetate.
Dirithromycin:
White or practically white powder. Very slightly soluble in water; very soluble in methanol and in methylene chloride.
Disopyramide Phosphate:
White or practically white, odorless powder. Melts at about 205
, with decomposition. Freely soluble in water; slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Disulfiram:
White to off-white, odorless, crystalline powder. Very slightly soluble in water; soluble in acetone, in alcohol, in carbon disulfide, and in chloroform.
Dobutamine Hydrochloride:
White to practically white, crystalline powder. Sparingly soluble in water and in methanol; soluble in alcohol and in pyridine.
Docusate Calcium:
White, amorphous solid, having the characteristic odor of octyl alcohol. It is free of the odor of other solvents. Very slightly soluble in water; very soluble in alcohol, in polyethylene glycol 400, and in corn oil.
Docusate Potassium:
White, amorphous solid, having a characteristic odor suggestive of octyl alcohol. Sparingly soluble in water; very soluble in solvent hexane; soluble in alcohol and in glycerin.
Docusate Sodium:
White, wax-like, plastic solid, having a characteristic odor suggestive of octyl alcohol, but no odor of other solvents. Sparingly soluble in water; very soluble in solvent hexane; freely soluble in alcohol and in glycerin.
NF category: Wetting and/or solubilizing agent.
Dolasetron Mesylate:
White to off-white powder. Freely soluble in water and in propylene glycol; slightly soluble in alcohol and in saline TS.
Dopamine Hydrochloride:
White to off-white, crystalline powder. May have a slight odor of hydrochloric acid. Melts at about 240
, with decomposition. Freely soluble in water and in aqueous solutions of alkali hydroxides; soluble in methanol; insoluble in ether and in chloroform.
Dorzolamide Hydrochloride:
White to off-white, crystalline powder. Soluble in water.
Doxapram Hydrochloride:
White to off-white, odorless, crystalline powder. Melts at about 220
. Soluble in water and in chloroform; sparingly soluble in alcohol; practically insoluble in ether.
Doxorubicin Hydrochloride:
Red-orange, hygroscopic, crystalline powder. Soluble in water, in isotonic sodium chloride solution, and in methanol; practically insoluble in chloroform, in ether, and in other organic solvents.
Doxycycline:
Yellow, crystalline powder. Very slightly soluble in water; freely soluble in dilute acid and in alkali hydroxide solutions; sparingly soluble in alcohol; practically insoluble in chloroform and in ether.
Doxycycline Hyclate:
Yellow, crystalline powder. Soluble in water and in solutions of alkali hydroxides and carbonates; slightly soluble in alcohol; practically insoluble in chloroform and in ether.
Doxylamine Succinate:
White or creamy white powder, having a characteristic odor. Very soluble in water and in alcohol; freely soluble in chloroform; very slightly soluble in ether and in benzene.
Droperidol:
White to light tan, amorphous or microcrystalline powder. Practically insoluble in water; freely soluble in chloroform; slightly soluble in alcohol and in ether. Melts at about 145
.
Absorbable Dusting Powder:
White, odorless powder.
Dyclonine Hydrochloride:
White crystals or white crystalline powder, which may have a slight odor. Exhibits local anesthetic properties when placed upon the tongue. Soluble in water, in acetone, in alcohol, and in chloroform.
Dydrogesterone:
White to pale yellow, crystalline powder. Practically insoluble in water; sparingly soluble in alcohol.
Dyphylline:
White, odorless, extremely bitter, amorphous or crystalline solid. Freely soluble in water; sparingly soluble in alcohol and in chloroform; practically insoluble in ether.